Evolution of the Deng Lab
With a main focus on patient care and overall outcomes, the Deng Lab has continued to evolve to explore the area from a multitude of different perspectives.
Feel free to click on a publication to learn more.
Feel free to click on a publication to learn more.
Early publications focused on organization of multidisciplinary care and clinical outcomes in advanced heart failure, mechanical support, and heart transplantation.
The Impact of Heart Failure Severity on Outcome in Cardiac Transplant Candidates
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From this emerged the translational interest of the relationship between immunological activation and cardiovascular outcomes, which led to the AlloMapTM project. Over the last 20 years, we have co-developed the first diagnostic gene expression profiling biomarker test in transplantation medicine. It gained US-FDA-regulatory clearance and international evidence-based medicine guideline acceptance to rule out rejection without invasive biopsies.
Related to the AlloMapTM project is the ongoing Advanced Heart Failure Organ Dysfunction project. Based on the AlloMapTM success, we were invited to expand this work to develop a similar biomarker test to
1) better understand HF-related frailty and organ dysfunction
2) better diagnose and predict outcomes
3) better treat HF-related organ dysfunction
Our hypothesis is that interaction between leukocyte and endothelial cells has the potential to worsen organ dysfunction and activate the immune system, leading to uncontrolled systemic inflammatory response, MOD, and death. We are now expanding on this work to develop a genomic blood test to better predict outcomes in patients with various forms of heart failure (MyLeukoMAPTM).
An Integrative Model of Leukocyte Genomics and Organ Dysfunction in Heart Failure Patients Requiring Mechanical Circulatory Support
Association between Preoperative Peripheral Blood Mononuclear Cell Gene Expression Profiles, Early Postoperative Organ Function Recovery Potential and 1 Year Survival Status in Advanced Heart Failure Patients Undergoing Mechanical Circulatory Support Implantation
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Integrating these clinical-translational projects is the lab’s systems biological conceptual work.
"Good Enough Solutions" and the Genetics of Complex Diseases
The Multidimensional Perspective of Cardiac Allograft Rejection
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Linking systems biology back into the clinical framework of a humanistically sound high–tech modern medicine encounter is reflected in my most recent research collaboration with Prof. Federica Raia in the “Relational Medicine” project.
The Relational Act – A Model to Improve the Practice of Medicine
Generalizing the Relational Act Framework: Encountering the Other and the Self
Relational Medicine – Personalizing Modern Healthcare: The Practice of High-Tech Medicine As A Relational Act
Artificial Heart Pumps – Bridging the Gap Between Science, Technology and Personalized Medicine by Relational Medicine
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