Projects
Dr. Mario Deng's Advanced Heart Failure Research Team is committed to studying the effects of Multi-Organ Dysfunction within Advanced Heart Failure Patients undergoing Mechanical Circulatory Support or Heart Transplantation at the UCLA Ronald Reagan Medical Center.
Project 1: Association Peripheral Blood Mononuclear Gene Expression Profiling and Early Postoperative Organ Function Recovery with 1-Year Survival in Advanced Heart Failure Patients
The major goal is to develop a novel approach to integrating gene expression data with clinical phenotype parameters for stratification of end stage heart failure patients who are receiving mechanical circulatory support device and are at high risk of developing multi-organ dysfunction syndrome.
Project 2: Aging & Functional Recovery Potential In Advanced Heart Failure
Our central hypothesis is that organ dysfunction and patient death after mechanical circulatory support- or heart transplantation-surgery is resulting from innate and adaptive immune cell dysfunction reflecting an age-related reduced “Functional Recovery Potential (FRP)” that can be predicted by a multidimensional molecular biomarker (MMB) test.
Project 3: Retrospective Validation of Functional Recovery Potential Across 7 Years of Heart Failure Patients
The long-term objective is to develop and validate a prognostic gene set based on a specifically developed leukocyte gene chip to noninvasively predict survival outcomes in heart failure (MyLeukoMAPTM).
Project 4: Multidimensional Molecular Biomarkers in Heart Failure
The goal is to develop a preoperative test to assist in precisely predicting postoperative outcome after mechanical circulatory support- and heart transplantation surgery.
We propose to use leukocyte immunobiology information to develop such a preoperative test to predict short term postoperative organ function changes that, as our preliminary data suggest, correlate with 1-year survival.
We propose to use leukocyte immunobiology information to develop such a preoperative test to predict short term postoperative organ function changes that, as our preliminary data suggest, correlate with 1-year survival.
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